Ya, I apply experimental lubes by hand and there is nothing easy or fast about it. Smear it into the grooves, run the bullet through the sizer, repeat to fill in spots that were missed the first time. I try to use an oversize die, especially with hard lubes, because otherwise hard lubes can squeeze the bullet in the die. For hard lubes, it is usually necessary to warm the lube, just warm enough so that you can smear the lube with your fingers.
If I am mainly interested in chrono numbers, then 10 shots is enough, so I only have to hand-lube 10 bullets. 10 shots over the chrono is enough to show a statistically significant difference, if there is one.
If I want to test accuracy, then I'll usually load enough for 3 groups plus maybe an extra round or three to condition the barrel (any time you switch lubes at the range, you need to either clean the barrel, or shoot a few foulers, or both).
Three groups is rarely enough to prove a statistically significant difference in accuracy, but it's a start. If the results are interesting, I'll load enough for 3 more groups and repeat the test another day. Then I take the results from all 6 groups and compare it to 6 groups from the control load, preferably tested on the same day, and check for statistical significance. And even then I'm not sure, The standard deviation of group size is typically 30%, making it tough to prove that a small change in accuracy is statistically significant.
Your question about lubes made me wish that my reloading operation and shooting range were set up. There are so many shooting experiments that I want to do.......